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Rfam 11.0: 10 years of RNA families.

TitleRfam 11.0: 10 years of RNA families.
Publication TypeJournal Article
Year of Publication2013
AuthorsBurge SW, Daub J, Eberhardt R, Tate J, Barquist L, Nawrocki EP, Eddy SR, Gardner PP, Bateman A
JournalNucleic Acids Res
Volume41
IssueDatabase issue
PaginationD226-32
Date Published2013 Jan
ISSN1362-4962
KeywordsBase Sequence, Databases, Nucleic Acid, Genomics, Internet, Molecular Sequence Annotation, Nucleic Acid Conformation, RNA, Untranslated, Sequence Alignment, User-Computer Interface
Abstract

The Rfam database (available via the website at http://rfam.sanger.ac.uk and through our mirror at http://rfam.janelia.org) is a collection of non-coding RNA families, primarily RNAs with a conserved RNA secondary structure, including both RNA genes and mRNA cis-regulatory elements. Each family is represented by a multiple sequence alignment, predicted secondary structure and covariance model. Here we discuss updates to the database in the latest release, Rfam 11.0, including the introduction of genome-based alignments for large families, the introduction of the Rfam Biomart as well as other user interface improvements. Rfam is available under the Creative Commons Zero license.

DOI10.1093/nar/gks1005
Alternate JournalNucleic Acids Res.
PubMed ID23125362
PubMed Central IDPMC3531072
Grant ListWT098051 / / Wellcome Trust / United Kingdom
/ / Howard Hughes Medical Institute / United States