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Rfam: annotating non-coding RNAs in complete genomes.

TitleRfam: annotating non-coding RNAs in complete genomes.
Publication TypeJournal Article
Year of Publication2005
AuthorsGriffiths-Jones S, Moxon S, Marshall M, Khanna A, Eddy SR, Bateman A
JournalNucleic Acids Res
Volume33
IssueDatabase issue
PaginationD121-4
Date Published2005 Jan 1
ISSN1362-4962
KeywordsAnimals, Base Sequence, Databases, Nucleic Acid, Genome, Humans, RNA, Untranslated, Sequence Alignment
Abstract

Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/.

DOI10.1093/nar/gki081
Alternate JournalNucleic Acids Res.
PubMed ID15608160
PubMed Central IDPMC540035